The county features several prominent peaks, including Horton Hill (988 feet), Wamble Mountain (942 feet), and Cave Hill (922 feet). In 2016, Camel Rock at the Garden of the Gods was featured on the Illinois Quarter as part of the America the Beautiful Quarter Launch. Shawnee National Forest is located in parts of Saline County, with recreation areas such as Garden of the Gods Recreation Area and Old Stone Face.

Glen O. Jones Fish and Wildlife Area and Sahara Woods Fish and Wildlife Area—both state-managed natural areas—are located within Saline County.